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Successfully developed Pd metal aerogel for photothermal enhanced chemokinetic therapy of MRSA bacterial infection
Release time:
2024-02-25 20:50
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Recently, the team of the "Molecular Imaging Probe Laboratory" of the Cancer Research Institute of Hengyang Medical College, Nanhua University successfully developed a Pd metal aerogel that can be used for photothermal enhanced chemokinetic therapy of MRSA bacterial infection. The relevant research achievements were titled "norepinephrine induced hydrophilic palladium aerogel with photothermal enhanced multi enzyme like activity for chemokinetic treatment of MRSA infection", and were published in the high-level SCI journal Journal of Chemical Engineering Publish research papers on.
Nanoenzymes have broad-spectrum antibacterial activity and good stability, and strong functionalization ability, making them an ideal alternative to antibiotics. The "Molecular Imaging Probe Laboratory" team innovatively selected norepinephrine (NE) to induce and synthesize a Pd metal aerogel, which has high hydrophilic properties and multiple enzyme like activities, and is used for photothermal enhanced chemokinetic therapy of MRSA bacterial infection. The prepared NE Pd aerogel has satisfactory peroxidase like and oxidase like activities, can produce a large number of hydroxyl radicals and superoxide anion radicals, decompose biofilm components, and cause irreversible damage to bacteria without drug resistance. The glutathione like peroxidase activity of NE Pd aerogel can also consume GSH in the bacterial microenvironment, thus regulating the infection microenvironment, enhancing the production of reactive oxygen species (ROS), and thus improving the chemical kinetics effect. In addition, the intrinsic photothermal activity of NE Pd aerogel can produce high heat to damage bacteria, and further promote enzyme like activity to eliminate bacteria and their biofilms. The results of animal skin wound model further showed that NE Pd aerogel could effectively treat wound infection caused by MRSA, and had good biocompatibility in vivo. This work shows that NE Pd aerogel nanoenzyme, as a synergistic photo thermal catalytic antibacterial agent, has great potential in treating bacterial infections and accelerating wound healing.
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